A new model of acquired lymphedema in the mouse hind limb: a preliminary report.
Identifieur interne : 004551 ( Main/Exploration ); précédent : 004550; suivant : 004552A new model of acquired lymphedema in the mouse hind limb: a preliminary report.
Auteurs : Kohei Oashi [Japon] ; Hiroshi Furukawa ; Akihiko Oyama ; Emi Funayama ; Toshihiko Hayashi ; Akira Saito ; Yuhei YamamotoSource :
- Annals of plastic surgery [ 1536-3708 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Lymphoedème.
- Animaux, Membre pelvien, Modèles animaux de maladie humaine, Souris.
English descriptors
- KwdEn :
- MESH :
- pathology : Lymphedema.
- Animals, Disease Models, Animal, Hindlimb, Mice.
Abstract
Lymphedema is known to be caused by many pathologic conditions; however, its correct diagnosis and optimal therapeutic strategies remain to be established. In this report, we describe an experimental model for acquired lymphedema in the lower extremity of the mouse that creates a lymphatic block in the groin induced by both radiation treatment and surgical division of the superficial and deep lymphatics. To evaluate the lymphatic system in this model, an indocyanine green fluorescence-sensitive camera system was used. This model has the advantages of relative technical simplicity and cost-effective use of a rodent animal model. Furthermore, a greater range of research tools such as antibodies and various databases are available for mice. This mouse model may be useful to anyone modeling lymphedema mechanisms, by providing a defined molecular context.
DOI: 10.1097/SAP.0b013e31821ee3dd
PubMed: 21629054
Affiliations:
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Le document en format XML
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last="Oyama">Akihiko Oyama</name></author><author><name sortKey="Funayama, Emi" sort="Funayama, Emi" uniqKey="Funayama E" first="Emi" last="Funayama">Emi Funayama</name></author><author><name sortKey="Hayashi, Toshihiko" sort="Hayashi, Toshihiko" uniqKey="Hayashi T" first="Toshihiko" last="Hayashi">Toshihiko Hayashi</name></author><author><name sortKey="Saito, Akira" sort="Saito, Akira" uniqKey="Saito A" first="Akira" last="Saito">Akira Saito</name></author><author><name sortKey="Yamamoto, Yuhei" sort="Yamamoto, Yuhei" uniqKey="Yamamoto Y" first="Yuhei" last="Yamamoto">Yuhei Yamamoto</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:21629054</idno><idno type="pmid">21629054</idno><idno type="doi">10.1097/SAP.0b013e31821ee3dd</idno><idno type="wicri:Area/PubMed/Corpus">002605</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002605</idno><idno 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Hokkaido at Sapporo, Sapporo, Japan. ko03252000)yahoo.co.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Hokkaido at Sapporo, Sapporo</wicri:regionArea><wicri:noRegion>Sapporo</wicri:noRegion></affiliation></author><author><name sortKey="Furukawa, Hiroshi" sort="Furukawa, Hiroshi" uniqKey="Furukawa H" first="Hiroshi" last="Furukawa">Hiroshi Furukawa</name></author><author><name sortKey="Oyama, Akihiko" sort="Oyama, Akihiko" uniqKey="Oyama A" first="Akihiko" last="Oyama">Akihiko Oyama</name></author><author><name sortKey="Funayama, Emi" sort="Funayama, Emi" uniqKey="Funayama E" first="Emi" last="Funayama">Emi Funayama</name></author><author><name sortKey="Hayashi, Toshihiko" sort="Hayashi, Toshihiko" uniqKey="Hayashi T" first="Toshihiko" last="Hayashi">Toshihiko Hayashi</name></author><author><name sortKey="Saito, Akira" sort="Saito, Akira" uniqKey="Saito A" first="Akira" last="Saito">Akira Saito</name></author><author><name sortKey="Yamamoto, Yuhei" sort="Yamamoto, Yuhei" uniqKey="Yamamoto Y" first="Yuhei" last="Yamamoto">Yuhei Yamamoto</name></author></analytic><series><title level="j">Annals of plastic surgery</title><idno type="eISSN">1536-3708</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Hindlimb</term><term>Lymphedema (pathology)</term><term>Mice</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Lymphoedème (anatomopathologie)</term><term>Membre pelvien</term><term>Modèles animaux de maladie humaine</term><term>Souris</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Hindlimb</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Membre pelvien</term><term>Modèles animaux de maladie humaine</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphedema is known to be caused by many pathologic conditions; however, its correct diagnosis and optimal therapeutic strategies remain to be established. In this report, we describe an experimental model for acquired lymphedema in the lower extremity of the mouse that creates a lymphatic block in the groin induced by both radiation treatment and surgical division of the superficial and deep lymphatics. To evaluate the lymphatic system in this model, an indocyanine green fluorescence-sensitive camera system was used. This model has the advantages of relative technical simplicity and cost-effective use of a rodent animal model. Furthermore, a greater range of research tools such as antibodies and various databases are available for mice. This mouse model may be useful to anyone modeling lymphedema mechanisms, by providing a defined molecular context.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Funayama, Emi" sort="Funayama, Emi" uniqKey="Funayama E" first="Emi" last="Funayama">Emi Funayama</name><name sortKey="Furukawa, Hiroshi" sort="Furukawa, Hiroshi" uniqKey="Furukawa H" first="Hiroshi" last="Furukawa">Hiroshi Furukawa</name><name sortKey="Hayashi, Toshihiko" sort="Hayashi, Toshihiko" uniqKey="Hayashi T" first="Toshihiko" last="Hayashi">Toshihiko Hayashi</name><name sortKey="Oyama, Akihiko" sort="Oyama, Akihiko" uniqKey="Oyama A" first="Akihiko" last="Oyama">Akihiko Oyama</name><name sortKey="Saito, Akira" sort="Saito, Akira" uniqKey="Saito A" first="Akira" last="Saito">Akira Saito</name><name sortKey="Yamamoto, Yuhei" sort="Yamamoto, Yuhei" uniqKey="Yamamoto Y" first="Yuhei" last="Yamamoto">Yuhei Yamamoto</name></noCountry><country name="Japon"><noRegion><name sortKey="Oashi, Kohei" sort="Oashi, Kohei" uniqKey="Oashi K" first="Kohei" last="Oashi">Kohei Oashi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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